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Mesothelioma
Attorneys, Mesothelioma Lawyers & Law Firms Guide
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Mesothelioma ResearchMalignant mesothelioma is a difficult disease to treat. The cancer can spread easily to nearby organs. If the tumor has spread, it is nearly impossible to remove the entire tumor surgically. In addition, it has been difficult to test the effectiveness of different treatments because there are relatively few cases of malignant mesothelioma.The primary treatment options for malignant mesothelioma are surgery, radiation therapy and chemotherapy. Surgery Before any surgery is considered for the treatment of malignant mesothelioma, the patient's overall health has to be evaluated. Tests are done to make sure the cancer has not spread to distant sites, and to evaluate how well the patient's lungs and heart are functioning. Lung tests look for any signs of lung damage from tobacco or from other diseases, including asthma and chronic obstructive pulmonary disease (COPD). These tests determine how risky surgery would be, especially if a lung needs to be removed. Surgery for malignant mesothelioma can be aimed at long-term control of the cancer (aggressive surgery) or relief of symptoms (palliative procedures). Aggressive surgery — A procedure called extrapleural pneumonectomy involves removal of the pleura, the lung, the diaphragm and the pericardium. The intent of this very aggressive, complicated surgery is to remove as much of the tumor as possible. Not all centers will perform this procedure because of its complexity and because it carries a high risk of death within 30 days after surgery. Extrapleural pneumonectomy typically is done only in younger patients who are in good overall health with stage I disease. Patients are evaluated carefully to determine their ability to tolerate the surgery. Palliative procedures — When malignant mesothelioma is advanced, palliative procedures can be done to relieve or control symptoms such as breathlessness, which are caused by fluid or by the tumor pressing on the lung or other organs. These procedures do not cure the disease. A procedure called thoracentesis can be used to treat fluid collection (effusion) in pleural mesothelioma. A needle is inserted into the chest to drain the fluid, relieving breathlessness and pain. Talc may be injected into the pleural space to try to stop fluid from accumulating there. This procedure is called talc pleurodesis. Similar procedures are used to relieve fluid collection (ascites) in peritoneal mesothelioma (paracentesis). A procedure called pleurectomy and decortication is the surgical removal of the pleura. This procedure can be done to reduce pain caused by the tumor or to prevent the fluid from accumulating. For peritoneal mesothelioma, surgery generally is aimed at relieving symptoms. Radiation Therapy Because of the location of malignant mesothelioma, it is extremely difficult to deliver high enough doses of radiation to kill the tumor without damaging the surrounding organs. Lower doses of radiation can help to shrink the tumor, but it is unclear whether this helps people to survive longer than if they were not treated. Using radiation therapy after surgery has not been shown to improve survival. However, because surgery is very unlikely to remove the entire tumor, radiation commonly is done after surgery in the hopes of killing remaining tumor cells. In addition, radiation therapy can be used to relieve the symptoms of mesothelioma, including chest pain. Chemotherapy Chemotherapy is the use of medications to treat cancer. Chemotherapy cannot cure mesothelioma. Some chemotherapy drugs have a partial effect in some patients. Combination chemotherapy (using more than one drug at the same time) may be given in an attempt to improve the patient's response to the medications. Some combinations have shown some promise, and some new medications are being tried. Like radiation therapy, chemotherapy may be administered after surgery in an attempt to kill cancer cells that could not be removed during the procedure. |
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